Zinc is a cofactor for over 300 enzymes and is essential for a wide range of physiological functions, including the regulation of intracellular signaling pathways in innate and adaptive immune cells. The homeostasis of zinc is particularly important for cell maturation and cell differentiation, cell cycle progression, and proper functioning of immune cells. In addition, zinc supports the body’s defense system by promoting healthy neutrophil, natural killer cell and T-lymphocyte function.^‡